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Sheldon Cooper can make a big bang all on his own. Welcome to MsMojo, and today we’re counting down our picks for the times Sheldon's quirky personality went supernova, resulting in some of the funniest meltdowns in “The Big Bang Theory.”

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00:00All I need is a healthy ovum, and I can grow my own Leonard Nimoy.
00:04Welcome to Ms. Mojo, and today we're counting down our picks for the times Sheldon's quirky
00:08personality went supernova, resulting in some of the funniest meltdowns in the Big Bang
00:13Theory.
00:14Bongo solo!
00:20Number 10.
00:22Sheldon faces a string theory crisis.
00:24Sheldon's first love may always be physics, but like all relationships, it has its ups
00:29and downs.
00:30After a heart-to-heart with Penny, he decides it's time to break up with string theory.
00:35You and string theory sound like a relationship, and I know what it's like to be in one and
00:38realize it's never going to turn out the way you want.
00:42I said Leonard, you said no.
00:43Now, if you've ever gone through a breakup, you'll recognize all the stages.
00:48Maybe you two rebounded with your version of the Kardashians of science.
00:52Wait, what's wrong with geology?
00:53Let me put this in a way you'll understand, Penny.
00:56Do you remember how you explained to me that the Kardashians aren't real celebrities?
01:01Well, geology is the Kardashians of science.
01:04Or perhaps, like Sheldon, you've sought comfort at the bottom of a wine glass, only to wake
01:09up the next day with blurry memories and basically no memories of those regrettable phone calls.
01:14We've all been there, piecing together those fuzzy details, realizing, yeah, I probably
01:20shouldn't have done that.
01:22Phyos-Phenyl-Sulfide.
01:23Phyos-Phenyl-Sulfide.
01:24What's even more fun than ge-o?
01:27Hey, did you see the Lego movie?
01:33Number nine, I'm Batman.
01:35If there's one thing Sheldon Cooper can't handle, it's keeping secrets, especially from
01:40his favorite little buddy.
01:42So when Penny confides in him her doubts about her and Leonard's compatibility and swears
01:46him to secrecy, Sheldon, of course, cracks under pressure.
01:50I can't keep your secret, Penny.
01:51I'm going to fold like an energy-based de novo protein in conformational space.
01:57Like a Renaissance triptych.
01:59Like a cheap suit.
02:00His solution?
02:01Move out.
02:02Sheldon bounces between friends' places until Howard, fed up with his ramblings, gives him
02:07some funny-tasting milk and takes him home.
02:09Cue the hilarity.
02:11Still confused by Sheldon's extra-weird behavior, Leonard tries to get to the bottom of it,
02:16and Sheldon ends up spilling quite a few secrets in addition to the one he promised not to
02:21tell Leonard.
02:22Mom smokes in the car.
02:26Jesus is okay with it, but we can't tell Dad.
02:32Not that secret.
02:33The other secret.
02:34I'm Batman.
02:35Yeah, I'm a Sheldon.
02:37It's okay, though.
02:38Leonard promises he won't tell...Leonard.
02:41You said Penny told you a secret.
02:44What's the secret?
02:45Okay, I'll tell you, but you can't tell Leonard.
02:49I promise.
02:50Number 8.
02:51What up, Moon Pie?
02:52Isn't it the worst when you're halfway through a long trip and realize you've forgotten something
02:57crucial?
02:58Maybe you can let it go, or maybe you're more like Sheldon.
03:01You forgot your flash drive.
03:02You forgot your flash drive.
03:03You forgot your flash drive.
03:04You forgot your flash drive.
03:05You forgot your flash drive.
03:06You forgot your flash drive.
03:07You forgot your flash drive.
03:08You forgot your flash drive.
03:09Only 10 hours, 55 minutes to go.
03:11He drives everyone up the wall when he realizes he forgot his flash drive back home.
03:16In desperation, he calls Penny for help, but she can't resist having some fun with
03:21him first.
03:22Wrong box.
03:23Put it back.
03:24Oh, Sheldon, are these letters from your grandmother?
03:26Don't read those letters.
03:27Oh, look, she calls you Moon Pie.
03:30That is so cute.
03:31Put down the letters!
03:32Does she push his buttons a little too hard?
03:34Maybe.
03:35But there's no denying that watching him squirm as she toys with him is pure comedy gold.
03:40What up, Moon Pie?
03:41No one calls me Moon Pie but Meemaw.
03:45It's a bit cruel, sure, but Penny has an even easier time cracking Sheldon's brain
03:50than breaking his novelty puzzle box.
03:55Before Young Sheldon, we got occasional insights into Sheldon's childhood through anecdotes
04:00on The Big Bang Theory.
04:01Stop yelling!
04:02You're making Sheldon cry!
04:03I'll tell you what's making Sheldon cry, that I let you name him Sheldon!
04:07In this episode, Sheldon is dismayed to discover his students find him insufferable, so he
04:12turns to Penny for acting lessons to make himself more likable.
04:15Turns out, improvisation isn't Sheldon's strong suit.
04:19Luckily, we sell both shoes and yogurt here.
04:24You do?
04:27Yes, look up at the sign and remember improv is always about saying yes.
04:32He's not a fan of American classics, either.
04:34But no worries, he's got a screenplay based on fan fiction he wrote at 10 years old that
04:39he thinks rivals Tennessee Williams.
04:42And you think it's better than Tennessee Williams?
04:45Why don't we leave that for future generations to decide?
04:48Penny pushes him out of his comfort zone, and Sheldon commits so hard to the material
04:53that he blurs the line between reality and fiction.
04:56Hey, it turns out he can improvise after all.
04:59Mrs. Cooper, hey, it's Penny.
05:01Yeah, I think I broke your son.
05:03Hold on.
05:04Talk to your mother.
05:06Mommy, I love you.
05:08Don't let Spock take me to the future.
05:14Here's another example where Sheldon engages in some, let's call it post-breakup behaviors.
05:19When he and Amy reach an impasse in their relationship, they decide to part ways.
05:25I move our relationship terminate immediately.
05:29Seconded.
05:30There being no objections?
05:34The motion carries.
05:35The motion carries.
05:36Instead, Sheldon fills the void with a cat.
05:39Well, actually, a whole clouder of them.
05:42They're perhaps some of the cutest guest stars to ever appear on the series.
05:46But yes, this is probably one of his more unhinged moments.
05:50Richard Feynman?
05:51Edward Teller?
05:52Otto Frisch?
05:54Vazzles.
05:56Vazzles?
05:57I was going to name him Herman Von Helmholtz, but he's so vazzy.
06:02When Leonard is unable to talk Sheldon around, he calls in reinforcements.
06:06Sheldon's mother.
06:08Just when Mary thinks she's seen it all, she walks in on Sheldon's feline Manhattan project.
06:13I'd like you to meet Oppenheimer, Frisch, Penofsky, Feynman, Weiskopf.
06:19Yeah, I get it. You got a lot of cats, and you gave them cute Jewish names.
06:23Leave it to some classic parental reverse psychology to snap him out of it.
06:27I saw what you did there.
06:28He thinks he's such a smarty pants, he's no different from any man.
06:32You tell him not to do something, that's all they want to do.
06:35Number 5. Sheldon shows off his dark side of the moon.
06:39We all have our ways of dealing with fears, and for Sheldon, it's avoidance.
06:44But when he's up for an award that requires public speaking, his worst nightmare, he's forced to face it.
06:50Vision became blurry, and before I knew it...
06:53Oh dear.
06:55Oh my God!
06:57Sheldon? Sheldon, are you okay?
06:59Don't trample me.
07:01His friends rally around him with support, offering therapy, a sharp new suit, and even meditation.
07:07But nothing works.
07:08As a last resort, Penny suggests a little liquid courage, and it does the trick.
07:14Turns out, a tipsy Sheldon is also a budding stand-up comedian.
07:18Why did the chicken cross the Mobius strip to get to the same side?
07:23Bazinga!
07:26Neutron walks into a bar and asks, how much for a drink?
07:29The bartender says, for you, no charge.
07:32With his nerves calmed, he delivers an unforgettable speech.
07:36Though Sheldon himself doesn't remember a thing.
07:38Luckily, Penny and Leonard are there to help him piece together the events of the night before.
07:43This couldn't be any more humiliating.
07:46Give it a minute.
07:48Now for the astronomers in the audience, get ready to see the dark side of the moon.
07:53And here's Uranus.
07:56Number four, Sheldon gets a loom.
07:59Sheldon's not exactly the kind to make a good first impression.
08:02However, when he meets his new boss, he makes such a bad one that it costs him his job.
08:08I can't believe he fired me.
08:11Well, you did call him a glorified high school science teacher whose last successful experiment was lighting his own farts.
08:17At a loss without work, Sheldon turns to some quirkier experiments to fill his day,
08:22which include everything from perfecting scrambled eggs to creating luminous fish nightlights.
08:28Funnily enough, the loom in Luminous gives him a lightbulb moment.
08:32And by the time Leonard calls his mom, because no one snaps Sheldon out of a crisis quite like Mary,
08:37Sheldon's bought himself a loom.
08:39Honey, why'd you get a loom?
08:42I was working with luminous fish, and I thought, hey, loom.
08:48Anyway, when even a home-cooked meal doesn't ground Sheldon, Mary turns to plan B, and it works.
08:55You know how your daddy used to say that you can only fish for so long before you kind of throw a stick of dynamite in the water?
09:02Yeah.
09:03Well, I'm done fishing.
09:05Number three, the napkin.
09:08It doesn't take much to send Sheldon into a meltdown.
09:11Sometimes, it's as innocent as a Christmas present.
09:14Forget it.
09:15I'm not giving you a present.
09:16No, he's too late.
09:17I see it.
09:18That elf sticker says, To Sheldon.
09:20The die has been cast.
09:21The moving finger has writ.
09:23Hannibal has crossed the Alps.
09:25When Penny has the audacity to give him a gift, how dare she, Sheldon obsesses over what to get her in return.
09:31When gift exchange time arrives, his reaction to Penny's present, a signed Leonard Nimoy napkin, is so overwhelming, he can barely handle it.
09:40Sorry the napkin's dirty.
09:41Wiped his mouth with it.
09:48I possess the DNA of Leonard Nimoy.
09:51Only Sheldon could take something as small and priceless as a napkin and see the potential for human cloning.
09:57All I need is a healthy ovum and I can grow my own Leonard Nimoy.
10:01After his freakout, he briefly disappears, returning with what looks like the entire store's supply of bath sets.
10:07And when that still doesn't cut it, he pulls out the most un-Sheldon move ever.
10:12Leonard, look.
10:13Sheldon's hugging me.
10:17It's a Saturnalia miracle.
10:23Let's say your favorite barber is suddenly unavailable.
10:26What do you do?
10:27Do you shrug and turn to a different employee, or do you spiral into an existential crisis?
10:32Sheldon does the latter, even taking it to the extreme and tracking down his usual barber in the hospital.
10:38If you can hear me, move away from the light and toward the sound of these scissors.
10:45He's also hilariously disappointed that his lack of haircut doesn't bring about the end of the world.
10:51So, how does he cope?
10:52Don't let this be Sheldon playing bongos.
10:57Please don't let this be Sheldon playing bongos.
11:03Yep, he keeps everyone awake with his newfound hobby.
11:07If you thought Sheldon was annoying before, wait until you hear him with bongos.
11:11He may have woken up the entire building, but at least learns a valuable lesson in bongo safety.
11:17I play bongos walking down the stairs.
11:21Oh!
11:25Never play bongos walking down the stairs.
11:28Before we unveil our top pick, here are a few honorable mentions.
11:32Howard's card trick.
11:33Mean?
11:34Maybe.
11:35Hilarious?
11:36You betcha.
11:37Two of hearts.
11:38I hate you.
11:42Sheldon doesn't know the answer.
11:44We're surprised we can't also see smoke coming out of his ears.
11:47He doesn't have it.
11:49He's got squat.
12:00Hey, hey, I need your answer.
12:02Presenting Stephen Hawking with a boo-boo.
12:04Don't meet your heroes or present them with papers.
12:07Or if you do, triple-check you're working first.
12:10Oh, gosh golly, I made a boo-boo.
12:13And I gave it to Stephen Hawking.
12:20Great. Another feinter.
12:23The elevator freakout.
12:25That ping marks one too many changes for Sheldon's liking.
12:29This is a nightmare.
12:31What's with him?
12:33He won a Nobel Prize and his wife looks amazing.
12:35Oh, yeah, got it.
12:37The perfect wedding date.
12:38Who can't relate to dreaming up their own council of Sheldons when under stress?
12:42Do we grant laid-back Sheldon a seat on the council?
12:46Hey, whatever you guys want.
12:50I'm just chilling like Bob Dylan.
12:54Negative.
12:55Heck no.
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13:16Over the series, Sheldon has come up with some pretty eccentric ways to tackle the universe's mysteries.
13:22In one of the funniest moments, he completely loses touch with reality while wrestling with a physics problem he dubs the Search for the Toad of Truth.
13:30I don't need sleep. I need answers.
13:33I need to determine where in this swamp of unbalanced formulas squatteth the Toad of Truth.
13:39He gets so immersed in it that everything around him from marbles to his friend's lunches turns into visual aids.
13:46Except corn, because that would just be ridiculous.
13:49Here, you want my peas?
13:50Peas, perfect. They can be electrons.
13:53You want my corn?
13:54Don't be ridiculous.
13:58What would I do with corn?
13:59After abandoning all basic human needs in his quest for answers, he escapes the apartment and breaks into a kid's ball pit.
14:06Honestly, we don't think we'll ever stop laughing at Leonard chasing him around it.
14:11Even Jim Parsons clearly finds it hilarious.
14:14Bazinga!
14:15Bazinga!
14:19Bazinga!
14:23Bazinga!
14:25Which Sheldon moment made you say Bazinga? Let us know in the comments.
14:29Don't stop. Yes. Keep going. Just like that. Almost there. Almost there.
14:34Almost there.
14:37Do you agree with our picks? Check out this other recent clip from Ms. Mojo.
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